Dengue NS1/IgG/IgM combo test kit

Dengue viruses, transmitted by the Aedes aegypti and Aedes albopictus mosquitoes, are widely distributed throughout the tropical and subtropical areas of the world. There are four known distinct serotypes (dengue virus 1, 2, 3 and 4). In children, infection is often subclinical or causes a self-limited febrile disease. However, if the patient is infected subsequent times with a different serotype, a more severe disease, dengue hemorrhagic fever or dengue shock syndrome, is more likely to occur. Dengue is considered to be the most important arthropod-borne viral disease due to the human morbidity and mortality it causes. NS1 is a highly-conserved glycoprotein that is present at high concentrations in the sera of dengue-infected patients during the early clinical phase of the disease. Dengue NS1 antigen is found from the first day and up to 9 days after onset of fever in sample of primary or secondary dengue infected patients. Immune response includes lgM antibodies produced by the 3rd-5th day of symptoms and persist for 30-60 days. lgG antibodies appear near the 14th day and persist for life. Secondary infections often result in high fever and in many cases with hemorrhagic events and circulatory failure. Secondary infections show that lgG levels rise within 1-2 days after the onset of symptoms and induce an lgM response after 20 days of infection.